Relationship between the patient state index and sedation scale during dexmedetomidine sedation during spinal anesthesia

Background & Objectives: Dexmedetomidine, a highly selective α-2 adrenoceptor agonist, is widely used sedative during spinal anesthesia. Indices devised using processed electroencephalographic monitors are useful for identifying the level of sedation without disturbing patient. However, we lack studies on relationship between patient state index (PSI) and dexmedetomidine sedation. We investigated PSI scale in patients undergoing anesthesia.
 Methodology: This study entailed review anesthetic records who underwent under SEDLine™ monitoring. After intrathecal injection, 1 µg/kg was injected intravenously over 10 min, followed by maintenance infusion at 0.4 µg/kg/h 50 min. The PSI, mean blood pressure, heart rate, oxygen saturation were recorded regular intervals. patients’ ‘Observer’s Assessment Alertness/Sedation’ (OAA/S) scores measured repeatedly until deep (OAA/S ≤ 2) achieved. Spearman test to evaluate correlation value OAA/S score. cut-off 2 calculated receiver operating characteristic curve analysis.
 Results: values corresponding 5, 4, 3, 2, 86.56 ± 10.45, 76.90 13.99, 68.16 16.18, 61.48 15.26, 55.67 16.75, respectively (P < 0.001). coefficient 0.6228 76. pressure rate decreased significantly compared baseline 60 min after continuous 0.001).
 Conclusion: with progression Patient assessment could prove evaluating depth distressing patients.
 Abbreviations: BIS: Bispectral index; Dex: Dexmedetomidine; EEG: Electroencephalography; OAA/S: Alertness/Sedation’; PSI: SA: Spinal anesthesia
 Key words: Conscious Sedation; Electroencephalography
 Citation: Lee KH. Relationship Anaesth. pain intensive care 2022;27(1):53−58.
 DOI: 10.35975/apic.v27i1.2117
 Received: July 28, 2022; Reviewed: October 26, Accepted: 2022